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"Exploring the Interplay of HOMA-IR(Insulin Resistance), Insulin, and Glucose in Diabetic Cognitive Decline: A Correlation Analysis"


Navigating diabetes can feel overwhelming, but understanding the key players is crucial for effective management. In this blog, we’ll unpack essential concepts like fasting glucose, insulin, and HOMA-IR, revealing their intricate play with HbA1c. Whether you’re newly diagnosed, supporting someone with diabetes, or simply curious, we’ll translate complex science into bite-sized insights.

But diabetes goes beyond blood sugar. We’ll also delve into the emerging link between diabetes and cognitive decline, exploring its impact and potential implications. So, whether you’re actively managing diabetes or seeking a deeper understanding, this blog aims to empower you with knowledge and broaden your perspective.

Let’s explore not only the metabolic effects of diabetes but also its potential impact on cognitive health.

Ready to dive in? Join us on this journey to demystify diabetes and empower yourself with knowledge!

What is Diabetes Mellitus and Cognitive decline ??

Diabetes Mellitus often called as Diabetes is a metobollic disorder, chronic condition where your body struggles to regulate blood sugar (glucose) levels. This can happen due to insufficient insulin production or resistance to insulin’s effects. There are several types of diabetes mellitus, including type 1 diabetes, type 2 diabetes, gestational diabetes, and other less common forms.

  1. Type 1 Diabetes: In type 1 diabetes, the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. This results in little to no insulin production, leading to high blood sugar levels. Type 1 diabetes often develops during childhood or adolescence and requires lifelong insulin therapy.

  2. Type 2 Diabetes: Type 2 diabetes is characterized by insulin resistance, where the body’s cells become less responsive to insulin, and/or impaired insulin secretion by the pancreas. Initially, the pancreas compensates by producing more insulin, but over time, insulin production may decline. Type 2 diabetes is more common in adults but is increasingly diagnosed in children and adolescents due to rising obesity rates.

Is there a link between diabetes and cognitive decline??

Unfortunately , yes research shows a strong link between diabetes and cognitive decline, meaning people with diabetes are at increased risk for developing issues like memory problems, slowed thinking, and even dementia. 

While cognitive decline is commonly associated with aging, several factors can contribute to accelerated cognitive decline in patients with diabetes mellitus. 

In our recent diabetes project, we calculated cognitive tests and cognitive decline scored them to analyze the impact of insulin resistance (HOMA1 IR), insulin, and glucose on cognitively declined diabetic patients.

What are cognitive tests??

Cognitive tests are assessments designed to measure various aspects of your mental function, like memory, thinking, reasoning, language, and attention. They help identify potential cognitive impairment, which is a general term for difficulties with these mental abilities. Basically, this process involves answering simple questions and performing simple tests.

Cognitive Screening Tests

  1. Digit Span Forward & Backward( (DS ) — Forward<=7 & Backward<=5

  2. HVLT — total Recall<=14

  3. RCFT — RCFT(Score)<=17

  4. Verbal Fluency Test ( VF )- VF(FAS)<42 OR VF(Animals)<42

  5. Trail Making( TM ) Test- TM Part A Time — Only Numbers- >42 , TM Part B Time — Numbers & alphabets >101

  6. Clock in a Box Test- clock Total Score <=2

  7. WTAR-WTAR<=20

  8. GDS- GDS>=15

  9. IADL- IADL<=14

  10. MMSE- MMSE<=23

Based on the above 10 cognitive tests we calculated a cognitive score and categorised as Mild, Moderate and Severe Decline Patients.

Role & Correlation Analysis of HOMA, Insulin, Fasting Glucose and HBA1C on Cognitive Decline Patients

There’s growing evidence linking diabetes and its related factors like HOMA, insulin, and fasting glucose to an increased risk of cognitive decline and dementia.

HOMA-IR (Homeostatic Model Assessment of Insulin Resistance):

HOMA-IR is a measure of insulin resistance. It estimates how well the body responds to insulin. Insulin resistance refers to a condition where the body’s cells become resistant to the effects of insulin, leading to elevated blood sugar levels.

HbA1c, or glycated hemoglobin, is a blood test that measures the average blood sugar level over the past 2–3 months. It provides valuable information about a person’s long-term glycemic control, particularly in individuals with diabetes.

Let’s see the correlation analysis of HOMA-IR and HBA1c

In the above image,

Observed Strong Correlation (Coefficient Value of 0.95):

  • HbA1c and HOMA-IR share a significant association, with a coefficient value of 0.95.

  • This indicates that as HbA1c levels increase or decrease, HOMA-IR levels closely follow, and vice versa.

How the correlation analysis helps Clincians:

  • Identifying insulin resistance early through HbA1c and HOMA-IR monitoring allows for timely intervention and management strategies.

  • Targeting insulin resistance may not only improve glycemic control but also potentially mitigate the risk of cognitive decline in diabetic patients.

How it’s helpful for patients: 

  • Educating patients about the correlation between HbA1c and HOMA-IR can empower them to monitor their glycemic control and insulin resistance more effectively.

  • Encouraging regular monitoring of both markers can facilitate proactive management and potentially improve long-term health outcomes, including cognitive function.

Hence, monitoring both biomarkers provides a powerful toolkit for understanding insulin resistance in the context of cognitive decline.

Insulin & HBA1c Correlation Analysis:

Insulin is a peptide hormone, which means it’s a chain of amino acids produced by specialized cells in your pancreas, called beta cells. It plays a crucial role in regulating your blood sugar (glucose) levels, which is essential for overall health and energy production.

Observed Close Alignment:

HbA1c and Insulin are showing a solid connection with a coefficient value of 0.92. When HbA1c rises, Insulin levels tend to go up so this connection hints at the possibility that the body might be resisting insulin.

How it helps for Clinicans/Doctors:

The correlation between HbA1c and insulin levels guides treatment planning and management strategies for patients with diabetes. Clinicians can use this information to tailor treatment plans, including lifestyle modifications, pharmacotherapy, and insulin therapy, to achieve optimal glycemic control and reduce the risk of complications.

How it educates Patients:

  • Educating patients about the connection between HbA1c and insulin levels empowers them to take an active role in managing their diabetes and cognitive health.

  • Encouraging regular monitoring of both markers enables patients to track their progress, make informed lifestyle choices, and adhere to treatment plans effectively.

Therefore, keeping an eye on both markers is crucial for effective sugar management in cognitive decline.

Correlation Analysis of Fasting glucose and HBA1c:

Fasting glucose, or fasting blood sugar, is a blood test that measures the amount of glucose (sugar) circulating in your bloodstream after you haven’t eaten or drank anything (except water) for at least 8 hours, typically overnight.

Perfect Positive Correlation (Coefficient Value of 1):

Fasting glucose and HbA1c are perfectly in sync, meaning they move up or down together. This close connection (with a coefficient value of 1) shows a perfectly linear relationship, where changes in one directly reflect in the other.

How it helps for Doctors:

  • HbA1c reflects the average blood glucose levels over the past 2–3 months, while fasting glucose measures the current blood glucose level. The perfect correlation between the two means that doctors can rely on either measure to assess a patient’s overall glycemic control.

  • It simplifies the monitoring process for doctors, as they can use either fasting glucose or HbA1c interchangeably to evaluate a patient’s response to treatment and adjust therapy accordingly.

How it educates Patient:

  • Patients can be educated on the significance of monitoring either fasting glucose or HbA1c levels regularly to gauge their overall diabetes management.

  • Understanding that changes in fasting glucose levels are reflected in HbA1c values can empower patients to take proactive steps in managing their blood sugar levels and adhering to their treatment plans.

Hence, this makes it easier for doctors to understand and manage sugar levels in these patients.

Understanding HbA1c dynamics guides tailored interventions for metabolic health in cognitive decline. Coefficient values aid quick decision-making.


In conclusion, understanding the intricate relationship between glucose, insulin, and related biomarkers is essential for effective management of diabetes mellitus and its potential impact on cognitive health. Through correlation analysis, clinicians can gain valuable insights into patients’ glycemic control, insulin sensitivity, and risk of cognitive decline. Empowering patients with knowledge about these correlations enables them to actively participate in their diabetes management and overall well-being.

By working together, we can unlock the potential of this knowledge to combat diabetes, protect cognitive health, and ensure a brighter future for all.

Thank you for reading!!

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